Saturday, February 22, 2020

Ylindrospermopsin Alkaloids Research Paper Example | Topics and Well Written Essays - 2500 words

Ylindrospermopsin Alkaloids - Research Paper Example CHAPTER 1: INTRODUCTION The description of cylindrospermopsin alkaloids is such that they consist of three soluble water toxins that comprise of cylindrospermopsin (CYN) (1), 7-deoxy-cylindrospermopsin (7-deoxy-CYN) (2) and also 7-epi-cylindrospermopsin (7-epi-CYN) (3). Researchers have signaled towards certain problems related to the toxicological characteristics of these natural compounds, their existence in water and which was followed by their removal. The structural features of these alkaloids are in fact extraordinary comprising of a sulfonated tricyclic guanidine linked to a uracil ring. The beginning of this analysis centers on the isolation of these innate products followed by the investigation into the environmental impact of cylindrospermopsin alkaloids contamination. (1) Figure 1. The cylindrospermopsin alkaloids of cylindrospermopsin (1),7-deoxy-cylindrospermopsin (2) and 7-epi-cylindrospermopsin (3). 1.1 ISOLATION AND CHARACTERIZATION Credited to Moore and his team usin g a combination of NMR and mass spetroscopy, the extraction of Cylindrospermopsin (1) took place in 1992 from the cyanobacterium Cylindrospermopsis raciborskii. While 7-deoxy-cylindrospermopsin (2) was discovered in 1999, owing to the purification of cylindrospermopsin which was performed on a regular basis. It was also concluded that the derivate of cylindrospermopsin could also exist in the form of a pair of tautomers because of the fact that the uracil ring’s vinylic proton was not identified during the application of the H NMR technique as shown in figure 2. However, as every sample of 7-deoxy-cylindrospermopsin (2) was observed the incidence of the uracil group (4) was confirmed by examining the absorbance maximum (?max). Even... Credited to Moore and his team using a combination of NMR and mass spetroscopy, the extraction of Cylindrospermopsin (1) took place in 1992 from the cyanobacterium Cylindrospermopsis raciborskii. While 7-deoxy-cylindrospermopsin (2) was discovered in 1999, owing to the purification of cylindrospermopsin which was performed on a regular basis. It was also concluded that the derivate of cylindrospermopsin could also exist in the form of a pair of tautomers because of the fact that the uracil ring’s vinylic proton was not identified during the application of the H NMR technique as shown in figure 2. However, as every sample of 7-deoxy-cylindrospermopsin (2) was observed the incidence of the uracil group (4) was confirmed by examining the absorbance maximum (ÃŽ »max). Even though, the measurement of approximate quantity was not possible, it was evident that as a mixture of compounds the natural material indeed existed. The discovery of the 7-epi-cylindrospermopsin took place in 20 02 and it was originally established that it was synthesized with Aphanizomenon ovalisporum. The approximation of cylindrospermopsin’s relative stereochemistry was made by considering the unusualtautomer enol presence of the uracil D ring. To explain the concept, uracil D as described in structure 6 is a intramolecularly hydrogen linked to a nitrogen terminus of the guanidine group. The NMR evidence was made to be the basis of the product correlation which understandably led the research participants to conclude that structure 7 was the most appropriate and relevant description of cylindrospermopsin (1).

Thursday, February 6, 2020

David Cole Interviews Dr Franciscek Piper Research Paper

David Cole Interviews Dr Franciscek Piper - Research Paper Example The greatest tragedy, however, continues to be the conspiracy that the Holocaust never occurred. In my personal opinion, I don’t know how anyone in their right mind could think for a second that a million people were murdered in concentration camps. It seems David Cole’s facts are based on memories of Holocaust victims, fuzzy memories that are rough around the edges. If I met David Cole, I would ask him, â€Å"What is your worst memory? Please describe it in excruciating detail. I’ll take you to the location and you can tell me each detail exactly. If you can’t do that, then I won’t believe that ever happened to you. I’ll assume you’re making the whole thing up.† How does a society measure the number of deaths that occurred after a horrifying holocaust when the majority of victims lie in mass, un-numbered graves? To the base, the existence of a horrific event on facts that cannot be proven seems a little unfair. Sure, the initial estimate by the Russians was four million then later changed to one million. That’s still one million innocent people. We’ll never know the true number of victims, there’s no way to know that. David Cole claims that Dr. Piper’s memory of the gas chamber appears to be sketchy. Perhaps it is a fuzzy memory, but I’m sure there’s a reason behind that. Why would someone want to remember such a horrifying place? Wouldn’t the human brain involuntarily block that memory for survival purposes? Could a human being continue to live a happy life if he wasn’t able to suppress those memories? I don’t think so. Also, why would millions of other Jews make up such a story?